Piperazine ferulate
Piperazine ferulate
CAS: 171876-65-6
Molecular Formula: C18H26O4
Piperazine ferulate - Names and Identifiers
Piperazine ferulate - Physico-chemical Properties
| Molecular Formula | C18H26O4 |
| Molar Mass | 306.4 |
| Density | 1.061±0.06 g/cm3(Predicted) |
| Boling Point | 425.8±30.0 °C(Predicted) |
| pKa | 8?+-.0.20(Predicted) |
Piperazine ferulate - Standard
Authoritative Data Verified Data
This product is 3-methoxy-4-hydroxycinnamic acid terazin. Calculated as dried product, the content of C4H10N2 • 2C10H10O4 shall not be less than 99.0%.
Last Update：2024-01-02 23:10:35
Piperazine ferulate - Trait
Authoritative Data Verified Data
- This product is white or off-white flake crystal or crystalline powder; Odorless.
- This product is slightly soluble in water, slightly soluble in ethanol, and almost insoluble in chloroform.
absorption coefficient
operation in the dark. Take this product, precision weighing, add water to dissolve and quantitatively dilute the solution containing about 6ug per lml, according to UV-visible spectrophotometry (General 0401), the absorbance was measured at a wavelength of 310nm, and the absorption coefficient was 637 to 669.
Last Update：2022-01-01 13:32:05
Piperazine ferulate - Differential diagnosis
Authoritative Data Verified Data
- (1) take this product, add water to make a solution containing 6% per lml, according to UV-visible spectrophotometry (General 0401) determination, there is a maximum absorption at wavelengths of 287nm and 310nm, and a minimum absorption at a wavelength of 254nm.
- (2) the infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 969).
Last Update：2022-01-01 13:32:05
Piperazine ferulate - Exam
Authoritative Data Verified Data
acidity
take this product, add water to dissolve and dilute to make a solution containing about 0.lmg per lml, and determine it according to law (General rule 0631). The pH value should be 5~6.0.
Related substances
operation in the dark. Take this product, add methanol to dissolve and dilute to make a solution containing about 5mg per 1 ml, as a test solution; Take ferulic acid control and piperazine control, respectively, precision weighing, methanol was each added to dissolve and diluted to prepare a solution containing about 80ug of ferulic acid and 50ug of piperazine per 1 ml as a control solution (1) and a control solution (2). According to the thin layer chromatography (General 0502) test, absorb the above three solutions of 20 u1, respectively, on the same silica gel G thin layer plate, with ethyl acetate-methanol-concentrated ammonia solution (10:6:3) for the development of the agent, expand, dry, set the iodine vapor color, immediately check. The test solution shall not have more than 2 other impurity spots except the two main spots at the same position as the control solution (1) and the control solution (2), and compared with the control solution (1) showed the main spot, not deeper.
loss on drying
take this product, dry to constant weight at 80°C, weight loss shall not exceed 0.5% (General rule 0831).
ignition residue
take l.Og of this product and check it according to law (General rule 0841). The residue left shall not exceed 0.1%.
Heavy metals
The residue left under the item of taking the ignition residue shall not contain more than 10 parts per million of heavy metal when examined by law (General Principles 0821, Law II).
Last Update：2022-01-01 13:32:06
Piperazine ferulate - Content determination
Authoritative Data Verified Data
take this product about 0.2g, precision weighing, add glacial acetic acid dissolved in 20ml, add crystal violet indicator solution 1 drop, with perchloric acid titration solution (0.1 mol/L) titration to the solution is blue-green, and the result of the titration is corrected with a blank test. Each 1 ml of perchloric acid titration solution (0.1 mol/L) corresponds to 23.73mg of C4H10N2. 2C10H10O4.
Last Update：2022-01-01 13:32:06
Piperazine ferulate - Category
Authoritative Data Verified Data
anticoagulant.
Last Update：2022-01-01 13:32:06
Piperazine ferulate - Storage
Authoritative Data Verified Data
light shielding, sealed storage.
Last Update：2022-01-01 13:32:07
Piperazine ferulate - Piperazine Ferulate tablets
Authoritative Data Verified Data
This product contains piperazine Ferulate (C4H10N2 • 2C10H1004) should be the label amount of 90.0% ~ 110.0%.
trait
This product is white or off-white.
identification
take the test solution under the content determination item, according to ultraviolet-visible spectrophotometry (General 0401), there is a maximum absorption at the wavelength of 287nm and 310nm, there is minimal absorption at a wavelength of 254nm.
examination
- dissolution rate protected from light. Take this product, according to the dissolution and release determination method (General rule 0931 The first method), with water 1000ml as the dissolution medium, the rotation speed is 50 rpm, according to the law, after 30 minutes, take 10ml of the solution, filter, take 3ml of the filtrate with precision, put it in a 25ml(50mg specification) or 50ml(100mg specification) measuring flask, dilute it to the scale with water, shake it well, the dissolution amount of each tablet was calculated as measured by the method under the content measurement item. The limit is 75% of the labeled amount and shall be in accordance with the provisions.
- others shall be in accordance with the relevant provisions under the item of tablets (General rule 0101).
Content determination
operation in the dark. Take 10 tablets of this product, precision weighing, fine grinding, precision weighing an appropriate amount (about 30mg equivalent to piperazine Ferulate), put it in a 250ml measuring flask, add water to dissolve piperazine Ferulate and dilute it to the scale, shake well, filter, Take 5ml of continuous filtrate accurately, put it in a 100ml measuring flask, dilute it with water to the scale, shake well, and use it as a test solution, UV-visible spectrophotometry (General rule 0401), determination of absorbance at the wavelength of 310nm; Another piperazine Ferulate reference substance, water is added to dissolve and quantitatively dilute to make a solution containing about 6ug per lml, which is determined and calculated by the same method.
category
The same as piperazine Ferulate.
specification
(l)50mg (2)100mg
storage
light shielding, sealed storage.
Last Update：2022-01-01 13:32:07
Piperazine ferulate - Reference Information
| introduction | ferulic acid isooctanium is one of ferulic acid derivatives, which has anti-thrombotic, anti-inflammatory, analgesic and regulating human immune function, and has high medicinal value. Derivatives of ferulic acid also have many important uses in the food industry. For example, ferulic acid ester has high biological activity due to its inherent antioxidant and free radical scavenging effect, and has been confirmed to have chemical anti-cancer effect, and is currently in preclinical identification. |
| use | piperazine ferulate is mainly used for various glomerular diseases accompanied by microscopic hematuria and hypercoagulable state, such as nephritis, chronic nephritis, nephrotic syndrome, early uremia, coronary heart disease, cerebral infarction, vasculitis, etc. |
| preparation method | using ethyl ferulate acid and isooctanol as raw materials, p-methylbenzene sulfonic acid as catalyst, through transesterification reaction, one-pot synthesis of isooctyl ferulate acid ester. The results show that the green synthesis method is cheap and easy to obtain raw materials, no other toxic solvents are introduced, and the post-treatment operation is simple and has strong application value. |
| efficacy | piperazine ferulate is a synthetic drug, which not only has pure ingredients, but also has carried out a large number of long-term clinical experiments in strict accordance with international standards, fully confirming the safety and specific effects. This medicine is mainly used for the treatment of various nephritis, including acute and chronic nephritis, and it also has a relatively good therapeutic effect on uremia in the initial stage. It is worth mentioning that it is not a hormone drug, so it will not affect the human skeletal system during the use process, and the toxicity is very low, so it only needs to be checked regularly according to the doctor's requirements. Kidney function can be, there will be no obvious side effects. |
Last Update：2024-04-09 20:52:54
